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J Physiol 577:515 Hunt D, Raivich G, Anderson PN (2012) Activating transcription factor 3 and the nervous system

Association of PCSK1 Rs6234 with Obesity and Related Traits in a Chinese Han Population. PloS One, vol

However, tirzepatide also imitates a second hormone, called GIP, which, along with reducing appetite, is thought to improve how the body breaks down sugar and fat

All of that means you eat less and your blood sugar stays steadier

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Tirzepatide works on two hormone pathways instead of one, which may lead to stronger appetite suppression for some patients